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can i just take a break from ranting about politics
except of course to say
HEY NEWLY ELECTED TEA PARTY FOLKS
ARE YOU GOING TO SPEND THE NEXT TWO YEARS
DOING NOTHING BUT VOTING NO, JUST TO KEEP OBAMA
FROM BEING SUCCESSFUL
OR ARE YOU ACTUALLY GOING TO TRY AND VOTE YES TO SOME THINGS TO HELP THIS FRIGGEN COUNTRY
SO FUCKING SICK OF FOLKS ELECTED INTO OFFICE WHO JUST SIT THERE AND SAY NO TO HELP THEIR PARTY
EVEN WHEN YES MIGHT HELP THEIR COUNTRY!!!!!!
but im not talking about politics today
today i want to talk about the new hit tv show on showtime
THE BIG C
damn this show is good
and the acting amazing
and its already made me cry my eyes out several times
especially the season finale
but what it’s mostly got me doing
thinking about what i would do if i thought i only had a year or three to live
and then it got me thinking
that just maybe we all should live our lives as if we only have a year or three to live
those gifts, money, kindnesses, charity donations
that we planned on giving after we croak
how bout giving them now
when folks can actually look you in the eye and say THANK YOU
i don’t know kids
but this rock and roll chick
is planning on living my life large, proud
how bout you?
buy levitra discount
well kids i voted today
and i gotta say
i really hated the new voting system here in nyc
i loved going into the old-fashioned voting booths
and flipping the switches
reminded me of growing up and seeing my mom vote
and it all seeming so adult
first time i voted i felt like a huge person, not fat but awesome
it was the new
fill in the paper ballot
then scan it into a computer thing
there was no satisfying flipping of switches
nobody seemed to understand if the scanned paper should be up or down
it was very well un-sexy
not to mention
isn’t this all incredibly lousy for the environment
the trees and so on!!
i still feel an empty un-satisfying feeling when i buy a metro-card and slide it into the subway turnstyle
i so miss feeling the token in my hand
dropping it in the slot
everything metal is paper these days
it just feels good to feel a tangible thing
the switches of the voter booth
the small bagel subway token
a book that has paper, that you can flip thru while sitting in a cozy chair, a real newspaper that leaves bits of ink on your fingers and smells like the press it came from
i guess this whole voting thing today was one more old-fashioned satisfying thing that has been upgraded
but are all upgrades really an improvement
voting today felt sloppy and confusing
the damn metro-card machines never seem to want to accept my crumpled money
now its almost impossible to just go out and buy a friggen CD
i miss buying cd’s hell
i miss buying albums too for that matter
especially the import 45′s that came in brown paper
they felt so OUTLAW
i bought the sex pistols
god save the queen
in the import section of Jack’s music store in red bank new jersey
it was in a brown paper sleeve
it felt like buying drugs man
well i am digressing clearly
on other news
what i feel the democrats did right is LOTS
but few seem to know it
because of what the democrats did wrong
and COMPLETE failure to BRAG
i did not learn until this week
about Obama’s credit card reform work
thats a bit of major oversight on my part
now my credit card company can not just blatantly rip me off
my insurance company can not dump me for getting sick
my brother’s kids will not get kicked off his insurance until they are 26 and have some chance of getting their own
these are all good things
but we don’t hear about them
we hear all kinds of lies spread widely by a fierce loud and very alpha republican party that folks believe
hell i was even starting to believe a few of them
i do think the dems will take some butt kicking today
hope its not as bad as folks thing it will be
but i think its a lesson
that being humble is fine in private life
but when you’re in office
you need to stand up and BOAST
we need LOUDER
BIGGER BALLED DEMS
and we need them NOW!!
im gonna go find some switches and tokens to fondle
i need to get satiated
Article, publication date, and citation information can be found at http://pharmrev.aspetjournals.org.
Restless leg syndrome "afflicts a significant portion of our population and in a minority of cases can cause insomnia and other important consequences," said Dr. Robert Vorona, an associate professor at Eastern Virginia Medical School in Virginia who studies sleep disorders.
A correctly selected erectile dysfunction treatment will improve blood flow within the penile space and enlarge the working capabilities of the muscles and nerves responsible for the erection.
Flaxseed meal – Grind 2-4 tablespoons daily. Flaxseed meal is a better choice due to its fiber, lignan, and vitamin content, but flaxseed oil (1 tbsp daily) can be substituted.
The urethra, the channel in which urine and sperm flow, which runs along the underside of the corpora cavernosa.
For example, some studies have shown that chemicals released from muscle proteins when they're cooked at high temperatures could increase risk of prostate cancer in some, Mason said.
Uncontrolled, potentially life-threatening abnormal heart rhythms
Dynamic Infusion Cavernosometry
The physical examination can reveal clues for physical causes of erectile dysfunction. For example, if the penis does not respond as expected to touching, a problem in the nervous system may be the cause. Small testicles, lack of facial hair and enlarged breasts can point to hormonal problems such as hypogonadism with low testosterone levels. A reduced flow of blood as a result of atherosclerosis can sometimes be diagnosed by finding diminished arterial pulses in the legs or listening with a stethoscope for bruits (the sound of blood flowing through narrowed arteries). Unusual characteristics of the penis itself could suggest the root of the erectile dysfunction, for example, bending of the penis during erection could be the result of Peyronie's disease.
Suppressive assay. 2 x 105 purified splenic or intratumoral CD11b+ cells were added to 106 clonotypic CFSE-labeled splenocytes. They were then peptide pulsed and cultured for 3 d in 96-well flat-bottom plates. Sildenafil was added where indicated in the figures.
NMDA-induced erections were significantly blunted in diabetic rats compared with control rats
"Men who have erectile dysfunction but no known coronary disease should be evaluated for occult coronary disease and should be counseled about lifestyle," Sharlip confirmed. "The most important point is that primary-care physicians need to learn to ask whether a patient has erectile dysfunction, because it can be an early sign of heart disease."
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Regardless of the etiology of ED, a psychological component is almost always associated with this disorder. The ability to achieve erection is intimately connected to a man's self-esteem and sense of worth. Pure psychogenic ED is generally evident when a man reports that he has normal erections some of the time but is unable to achieve or to maintain a full erection at other times. Once the man has doubt regarding sexual performance, he loses confidence; thus, future attempts to have sexual relations provoke anxiety. These men are desperate for help and depend on the physician's advice. In many instances, the couple needs to work together to resolve the problem, although the relationship may be responsible for the problem. Most physicians do not have the time to work with these patients and, instead, refer them to a sexual counselor.
Cyclic nucleotide phosphodiesterases (PDEs) are enzymes that regulate the cellular levels of the second messengers, cAMP and cGMP, by controlling their rates of degradation. There are 11 different PDE families, with each family typically having several different isoforms and splice variants. These unique PDEs differ in their three-dimensional structure, kinetic properties, modes of regulation, intracellular localization, cellular expression, and inhibitor sensitivities. Current data suggest that individual isozymes modulate distinct regulatory pathways in the cell. These properties therefore offer the opportunity for selectively targeting specific PDEs for treatment of specific disease states. The feasibility of these enzymes as drug targets is exemplified by the commercial and clinical successes of the erectile dysfunction drugs, sildenafil (Viagra), tadalafil (Cialis), and vardenafil (Levitra). PDE inhibitors are also currently available or in development for treatment of a variety of other pathological conditions. In this review the basic biochemical properties, cellular regulation, expression patterns, and physiological functions of the different PDE isoforms will be discussed. How these properties relate to the current and future development of PDE inhibitors as pharmacological agents is especially considered. PDEs hold great promise as drug targets and recent research advances make this an exciting time for the field of PDE research.
The researchers also reviewed the results of studies on erectile dysfunction in men with chronic heart failure. They noted that erectile dysfunction may arise from reduced blood flow to the penis, and that certain drugs used to treat chronic heart failure might actually exacerbate this problem.
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